Information and data related to search measures are most efficiently exchanged by means of international police cooperation. International police cooperation activities comprise exchange of information and data through organizations for international police cooperation between competent police authorities of two, or usually more, countries whereby police authorities act on requests from another country, based on national and international legislation. Depending on the legal framework, tree types of international police cooperation can be identified: universal regional and bilateral. The Croatian police are an active user of both types of international police cooperation, and exchange information through the INTERPOL and Europol channels and the Schengen Information System (SIS), i.e. through the S.I.Re.N.E. Office. The aim of this paper is to explain how search activities are implemented, i.e. international search as one of the key instruments of international police cooperation through available and used search instruments, and to highlight the similarities, differences, advantages and disadvantages of search activities implemented by means of universal and regional international police cooperation. Search activities through the INTERPOL channel and the Schengen Information System, although very similar and all the more so different, have the common goal of locating and arresting a person and making him/her available to the competent judicial authorities to achieve the purpose of punishment as one of the fundamental requirements for the proper functioning of every country.